Neutrophil α-Defensins Cause Lung Injury by Disrupting the Capillary–Epithelial Barrier

Comparison of Neutrophil Apoptosis α-Defensins and Calprotectin in Children with and without Severe Early Childhood Caries

Background: The infectious nature of severe early-childhood caries (S-ECC) points to the possible participation of immunologic host responses including neutrophils and their antimicrobial products. Objectives: The aim of this study was to determine the neutrophil apoptosis, α-defensins (HNP1-3) and calprotectin levels in the saliva of preschool children and the association with S-ECC. Methods: ...

Anti-inflammatory mechanisms of the neutrophil- released antimicrobial peptide α-defensins

...................................................................................................................................... I DECLARATION ................................................................................................................................ III ACKNOWLEDGEMENTS .....................................................................................................

Ventilator-Induced Lung Injury Barrier Disruption in Experimental Neutrophil-Derived IL-6 Limits Alveolar

θ-Defensins: Cyclic Antimicrobial Peptides Produced by Binary Ligation of Truncated α-Defensins

The first cyclic peptide discovered in animals is an antimicrobial octadecapeptide that is expressed in leukocytes of rhesus monkeys. The peptide, termed rhesus θ-defensin 1 (RTD-1) is the prototype of a new family of antimicrobial peptides, which like the previously characterized αand β-defensin families, possesses broad spectrum microbicidal activities against bacteria, fungi, and protects mo...

Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo

The α-defensins, human neutrophil peptides (HNPs) are the predominant antimicrobial peptides of neutrophil granules. They are synthesized in promyelocytes and myelocytes as proHNPs, but only processed in promyelocytes and stored as mature HNPs in azurophil granules. Despite decades of search, the mechanisms underlying the posttranslational processing of neutrophil defensins remain unidentified....